Endocrine Abstracts

Chronic heart failure (HF) is a major cause of morbidity and mortality in humans and domestic animals. HF is characterised by chronic inflammation and functional changes in non-cardiovascular tissues; obesity is also associated with low level chronic inflammation, with adipose tissue (AT) exhibiting infiltration of macrophages and alterations in fatty acid (FA) profiles. The aim of this project was to investigate expression of regulators of lipid metabolism and inflammation an...

Changes in maternal dietary intake during gestation can affect muscle development1 and may be linked to the catabolic actions of hormones, such as glucocorticoids, which inhibits the insulin like growth factor 1 (IGF1) pathway. This study examines the potential effects of glucocorticoids and skeletal muscle adaptations in seven-day-old offspring exposed to suboptimal gestational environments.Pregnant sows were randomly assigned to a commercial...

Background: Size at birth has been shown to have important consequences on later health, including the development of the metabolic syndrome. Tissue sensitivity to cortisol is regulated, in part, by the GCR and alterations in GCR expression have been observed in obesity and type 2 diabetes.Objectives: To examine whether birth weight influences the expression of GCR mRNA in skeletal muscle (SM) at days 7 and 14 of postnatal life.Met...